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KMID : 0380020210360040260
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Korean Journal of Biotechnology and Bioengineering
2021 Volume.36 No. 4 p.260 ~ p.271
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Study on Preparation, Characteristics and Dissolution Behavior of Interpenetrating Network Delivery System containing Fermented Rhodiola Rosea Extracts
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Jang Hyun-Sang
Lee Soo-Hwan
Cho Young-Ho
Lee Gye-Won
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Abstract
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In this study, interpenetrating network (IPN) containing Rhodiola rosea Ex., which can exhibit a high drug entrapment efficiency (DEE) without precipitaion, were prepared by changing the content of chitosan (CS), L-polyvinyl alcohol (L-PVA), and formaldehyde (FA) according to the central composite design. We were evaluated drug loading %, DEE %, and dissolution behavior for application as a oral drug delivery and optimize the formulation of IPN. IPN containing Rhodiola rosea Ex. could be stably prepared by soaking in 50% methanol and encapsulating over 90% without precipitation by freezing-thawing/gas blowing method. The drug loading %, DEE %, and dissolution rate of the prepared IPN were not affected by the content of CS, but were affected by the content L-PVA and FA and either showed a linear or quadratic pattern. By the results we could confirm that the mechanism of drug release from IPN is Korsmeyer-Peppas model by non-fickian diffusion. Optimized IPN (CS 4%, L-PVA 149.15%, and FA 203.51%) showed high overall satisfaction (0.9952). The IPN matrix tablet showed a higher dissolution rate and were stable during the 3 month at accelerated condition. Also, difference factor and similarity factor were 0~15 and 50~100 and there was no significant difference in bioequivalance between optimized IPN and IPN matrix tablet. These studies showed the application of quality by design (QbD) in formulation development of IPN matrix tablet containing Rhodiola rosea Ex., which can be used as a oral drug dleivery delivery system in view of stability and their dissolution characteristics.
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KEYWORD
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IPN matrix tablet, Rhodiola rosea Ex., similarity factor, non-fickian diffusion
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